Sci. Signal., 30 November 2010
Synthetic Biology Cellular Devices
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
Cellular control mechanisms might offer opportunities to build genetic devices capable of sensing aberrant cells and activate a regulatory signal that directs the cell to alter its biological state. Culler et al. (see the Perspective by Liu and Arkin) present a proof of principle for a synthetic gene network in which cells were engineered to make an RNA-based device that detected molecules associated with disease states such as inflammation and cancer. Detection then triggered expression of a gene that made the cells more sensitive to a drug causing cell death.
Citation: L. B. Ray, Cellular Devices. Sci. Signal. 3, ec367 (2010).
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