Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 11 January 2011
Vol. 4, Issue 155, p. ec14
[DOI: 10.1126/scisignal.4155ec14]

EDITORS' CHOICE

Neuroscience Mind the Gap (Junction)

Peter R. Stern

Science, AAAS, Cambridge CB2 1LQ, UK

The role of chemical synapses in learning and memory in the adult mammalian brain is well established. In contrast, the more rapid neuronal transmission that is mediated by electrical synapses is not fully understood. Using a variety of different manipulations—including fear conditioning, drugs, and electrophysiological recordings—in freely moving rats, Bissiere et al. discovered that blocking neuronal gap junctions containing connexin 36 controls the acquisition and the consolidation of fear memories within the dorsal hippocampus. It appears that interfering with gap junction–mediated neuronal transmission selectively prevented the formation of a memory during aversive experiences such as fear conditioning.

S. Bissiere, M. Zelikowsky, R. Ponnusamy, N. S. Jacobs, H. T. Blair, M. S. Fanselow, Electrical synapses control hippocampal contributions to fear learning and memory. Science 331, 87–91 (2011). [Abstract] [Full Text]

Citation: P. R. Stern, Mind the Gap (Junction). Sci. Signal. 4, ec14 (2011).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882