Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 25 January 2011
Vol. 4, Issue 157, p. pe3
[DOI: 10.1126/scisignal.2001764]


Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code

Christian Bronner*

CNRS UMR 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, 74 route du Rhin, B.P. 60024, 67401 Illkirch Cedex, France.

Abstract: Inheritance of DNA methylation patterns is a key mechanism involved in epigenetic cell memory transmission from mother cell to daughter cell. This occurs due to cooperation between the DNA methyltransferase DNMT1 and the ubiquitin ligase UHRF1 (ubiquitin-like, containing plant homeo domain and RING finger 1) in a macromolecular complex. Newly identified members of this complex are the acetyltransferase Tip60 (Tat-interactive protein) and the deubiquitinase HAUSP (herpes virus–associated ubiquitin specific protease), which exert tight regulation of DNMT1 abundance through a ubiquitylation-dependent process. It is important to determine how all of these actors communicate with each other and what signals coordinate their communication. In the case of DNMT1, the balance of UHRF1 and HAUSP activities might be influenced by the local environment, such as histone code, cell-cycle status, and local DNA methylation status.

* E-mail, christian.bronner{at}

Citation: C. Bronner, Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code. Sci. Signal. 4, pe3 (2011).

Read the Full Text

Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications.
A. Scott, J. Song, R. Ewing, and Z. Wang (2014)
Acta Biochim Biophys Sin 46, 199-203
   Abstract »    Full Text »    PDF »
GKN1-miR-185-DNMT1 Axis Suppresses Gastric Carcinogenesis through Regulation of Epigenetic Alteration and Cell Cycle.
J. H. Yoon, Y. J. Choi, W. S. Choi, H. Ashktorab, D. T. Smoot, S. W. Nam, J. Y. Lee, and W. S. Park (2013)
Clin. Cancer Res. 19, 4599-4610
   Abstract »    Full Text »    PDF »
ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation.
A. Shamma, M. Suzuki, N. Hayashi, M. Kobayashi, N. Sasaki, T. Nishiuchi, Y. Doki, T. Okamoto, S. Kohno, H. Muranaka, et al. (2013)
Mol. Cell. Biol. 33, 3113-3124
   Abstract »    Full Text »    PDF »
Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity.
L. Wang, Y. Liu, U. H. Beier, R. Han, T. R. Bhatti, T. Akimova, and W. W. Hancock (2013)
Blood 121, 3631-3639
   Abstract »    Full Text »    PDF »
Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein.
J. Cheng, Y. Yang, J. Fang, J. Xiao, T. Zhu, F. Chen, P. Wang, Z. Li, H. Yang, and Y. Xu (2013)
J. Biol. Chem. 288, 1329-1339
   Abstract »    Full Text »    PDF »
Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen.
R. Mi, L. Song, Y. Wang, X. Ding, J. Zeng, S. Lehoux, R. P. Aryal, J. Wang, V. K. Crew, I. van Die, et al. (2012)
J. Biol. Chem. 287, 41523-41533
   Abstract »    Full Text »    PDF »
The role of methyl-binding proteins in chromatin organization and epigenome maintenance.
A. Fournier, N. Sasai, M. Nakao, and P.-A. Defossez (2012)
Briefings in Functional Genomics 11, 251-264
   Abstract »    Full Text »    PDF »
Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression.
A. S. Olsen, M. P. Sarras Jr., A. Leontovich, and R. V. Intine (2012)
Diabetes 61, 485-491
   Abstract »    Full Text »    PDF »
Regulation of mammalian DNA methyltransferases: a route to new mechanisms.
H. Denis, M. N. Ndlovu, and F. Fuks (2011)
EMBO Rep. 12, 647-656
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882