Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 8 March 2011
Vol. 4, Issue 163, p. ec73
[DOI: 10.1126/scisignal.4163ec73]

EDITORS' CHOICE

Neuroscience Improving Old Memories

Peter R. Stern

Science, AAAS, Cambridge CB2 1LQ, UK

Can memory be improved? In vivo experiments using pharmacological inhibition of the enzyme protein kinase M{zeta} (PKM{zeta}) in the insular cortex have shown that long-term conditioned taste aversion memory can be blocked. Now, Shema et al. show that overexpression of PKM{zeta} in the rat insular cortex enhances memory, including memory that was formed long before the enzyme was overexpressed. The enhancement appears to affect more than a single memory. Thus, modulation of PKM{zeta} can alter memories, even months after the initial encoding.

R. Shema, S. Haramati, S. Ron, S. Hazvi, A. Chen, T. C. Sacktor, Y. Dudai, Enhancement of consolidated long-term memory by overexpression of protein kinase M{zeta} in the neocortex. Science 331, 1207–1210 (2011). [Abstract] [Full Text]

Citation: P. R. Stern, Improving Old Memories. Sci. Signal. 4, ec73 (2011).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882