Sci. Signal., 8 March 2011
Neuroscience Improving Old Memories
Peter R. Stern
Science, AAAS, Cambridge CB2 1LQ, UK
Can memory be improved? In vivo experiments using pharmacological inhibition of the enzyme protein kinase M (PKM) in the insular cortex have shown that long-term conditioned taste aversion memory can be blocked. Now, Shema et al. show that overexpression of PKM in the rat insular cortex enhances memory, including memory that was formed long before the enzyme was overexpressed. The enhancement appears to affect more than a single memory. Thus, modulation of PKM can alter memories, even months after the initial encoding.
R. Shema, S. Haramati, S. Ron, S. Hazvi, A. Chen, T. C. Sacktor, Y. Dudai, Enhancement of consolidated long-term memory by overexpression of protein kinase M in the neocortex. Science 331, 1207–1210 (2011). [Abstract] [Full Text]
Citation: P. R. Stern, Improving Old Memories. Sci. Signal. 4, ec73 (2011).
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