Sci. Signal., 29 March 2011
Science Signaling Podcast: 29 March 2011
Thomas G. Graeber1,2 and Annalisa M. VanHook3
1 Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center; David Geffen School of Medicine, Department of Molecular and Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Abstract: This Podcast features a conversation with the senior author of a Research Article published in the March 29 issue of Science Signaling. Thomas Graeber discusses his groups phosphoproteomic analysis of a leukemia cell line, which reveals a mechanism by which leukemia cells may become resistant to chemotherapeutic agents that target tyrosine kinases. They found that the sensitivity of leukemias driven by the Bcr-Abl fusion protein to tyrosine kinase inhibitors depends on the cells reliance on negative feedback mechanisms that limit the activity of the Src family of tyrosine kinases.
Citation: T. G. Graeber, A. M. VanHook, Science Signaling Podcast: 29 March 2011. Sci. Signal. 4, pc6 (2011).
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