Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 12 April 2011
Vol. 4, Issue 168, p. ec105
[DOI: 10.1126/scisignal.4168ec105]

EDITORS' CHOICE

Neuronal Polarization Energy Requirements for Neuronal Polarization

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Neuronal polarization lies at the heart of neuronal development, synaptic wiring, and interneuronal communication. Although much progress has been made in understanding axon growth and path finding, the mechanisms that regulate axonal neurite selection and polarity initiation remain poorly understood. Rapid axon growth requires a large quantity of building material and efficient intracellular transport. Coordination between axon initiation and cellular energy homeostasis may thus be important during the early stages of neuronal polarization. Using cultured hippocampal neurons and embryonic brain slices, Amato et al. investigated the role of adenosine monophosphate–activated protein kinase (AMPK), which is involved in the sensing and regulation of bioenergy homeostasis, in neuronal polarization. Up-regulation of AMPK activity reduced the proportion of neurons possessing a typical axon. The ability of AMPK to inhibit polarization was restricted to the early stages of polarization; AMPK activation after axon initiation did not affect polarization or axon growth.

S. Amato, X. Liu, B. Zheng, L. Cantley, P. Rakic, H.-Y. Man, AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science 332, 247–251 (2011). [Abstract] [Full Text]

Citation: S. M. Hurtley, Energy Requirements for Neuronal Polarization. Sci. Signal. 4, ec105 (2011).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882