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Sci. Signal., 26 April 2011
Vol. 4, Issue 170, p. pc8
[DOI: 10.1126/scisignal.2002099]


Science Signaling Podcast: 26 April 2011

Chuan-ju Liu1,2 and Annalisa M. VanHook3

1 Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
2 Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
3 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Report published in the April 22 issue of Science. Chuan-ju Liu discusses his group’s finding that the growth factor progranulin (PGRN) bound to the tumor necrosis factor receptor (TNFR) and antagonized signaling by TNFα. Mice lacking PGRN developed more severe inflammatory arthritis in response to immunization with collagen than normal mice, and PGRN treatment reduced the severity of symptoms in mouse models of rheumatoid arthritis.

Citation: C.-j. Liu, A. M. VanHook, Science Signaling Podcast: 26 April 2011. Sci. Signal. 4, pc8 (2011).

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