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Sci. Signal., 26 April 2011
Vol. 4, Issue 170, p. pe22
[DOI: 10.1126/scisignal.2002019]

PERSPECTIVES

PI3K and Chemotaxis: A Priming Issue?

Philippe V. Afonso and Carole A. Parent*

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract: Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.

* Corresponding author. E-mail, parentc{at}mail.nih.gov

Citation: P. V. Afonso, C. A. Parent, PI3K and Chemotaxis: A Priming Issue? Sci. Signal. 4, pe22 (2011).

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