Sci. Signal., 3 May 2011
Immunology Signal Stealer
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is expressed by activated and regulatory T cells and helps to prevent T cell–mediated immune responses from getting out of control. The costimulatory pair of ligands bind CTLA-4 and are expressed on antigen-presenting cells. CD80 and CD86 also bind to CD28 expressed on T cells, which is critical for T cell activation. Qureshi et al. (see the Perspective by Sakaguchi and Wing) find that CTLA-4, expressed by both human and mouse T cells, plucks CD80 and CD86 from the surface of antigen-presenting cells and internalizes them through trans-endocytosis. These findings suggest an extrinsic cell mechanism for the negative regulation of T cell immunity by CTLA-4.
O. S. Qureshi, Y. Zheng, K. Nakamura, K. Attridge, C. Manzotti, E. M. Schmidt, J. Baker, L. E. Jeffery, S. Kaur, Z. Briggs, T. Z. Hou, C. E. Futter, G. Anderson, L. S. K. Walker, D. M. Sansom, Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4. Science 332, 600–603 (2011). [Abstract] [Full Text]
Citation: K. L. Mueller, Signal Stealer. Sci. Signal. 4, ec125 (2011).
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