Sci. Signal., 3 May 2011
Structural Biology Complement Receptor Complex Structure
Science, AAAS, Washington, DC 20005, USA
Complement receptor 2 (CR2), found in B cells and follicular dendritic cells, binds to a ligand, C3d, which is bound to antigen. The antigen simultaneously binds to the B cell antigen recognition complex such that this coligation enhances the antibody response. A previously published crystal structure of the CR2:C3d complex possibly represented a nonphysiological interaction. Hence, van den Elsen and Isenman report a structure in which the molecular details of the interface are more consistent with biochemical data, supporting physiological relevance and providing a foundation for rational design of therapeutics against autoreactive B cells.
Citation: V. Vinson, Complement Receptor Complex Structure. Sci. Signal. 4, ec126 (2011).
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