Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 3 May 2011
Vol. 4, Issue 171, p. ec126
[DOI: 10.1126/scisignal.4171ec126]


Structural Biology Complement Receptor Complex Structure

Valda Vinson

Science, AAAS, Washington, DC 20005, USA

Complement receptor 2 (CR2), found in B cells and follicular dendritic cells, binds to a ligand, C3d, which is bound to antigen. The antigen simultaneously binds to the B cell antigen recognition complex such that this coligation enhances the antibody response. A previously published crystal structure of the CR2:C3d complex possibly represented a nonphysiological interaction. Hence, van den Elsen and Isenman report a structure in which the molecular details of the interface are more consistent with biochemical data, supporting physiological relevance and providing a foundation for rational design of therapeutics against autoreactive B cells.

J. M. H. van den Elsen, D. E. Isenman, A crystal structure of the complex between human complement receptor 2 and its ligand C3d. Science 332, 608–611 (2011). [Abstract] [Full Text]

Citation: V. Vinson, Complement Receptor Complex Structure. Sci. Signal. 4, ec126 (2011).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882