Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 10 May 2011
Vol. 4, Issue 172, p. pe25
[DOI: 10.1126/scisignal.2002046]

PERSPECTIVES

PP2A Phosphatases: The "On-Off" Regulatory Switches of Brassinosteroid Signaling

Simone Di Rubbo1,2, Niloufer G. Irani,1,2, and Eugenia Russinova1,2*

1 Department of Plant Systems Biology, VIB, Technologiepark 927, 9052 Gent, Belgium.
2 Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, 9052 Gent, Belgium.

Abstract: Inactivation of ligand-bound plasma membrane receptors is crucial for the regulation of their signaling outputs. The internalization of activated receptors and their subsequent targeting for recycling or degradation is controlled by posttranslational modifications, of which phosphorylation and dephosphorylation play an important role. Recent work suggests that a similar mechanism acts on the brassinosteroid (BR) receptor BR INSENSITIVE 1 (BRI1) in Arabidopsis thaliana to switch off BR signaling. The degradation of BRI1 requires a protein phosphatase 2A (PP2A)–mediated dephosphorylation that is specified by methylation of the phosphatase by a leucine carboxylmethyltransferase on membranes. PP2A is also reported to act positively on BR signaling by targeting the transcription factor BRASSINAZOLE-RESISTANT 1 (BZR1), a component downstream of BRI1. Thus, PP2A proteins play a dual role in the regulation of the BR pathway to switch between inhibition and activation of the BR signaling, depending on their substrate specificity and localization.

* Corresponding author. E-mail, jenny.russinova{at}psb.vib-ugent.be

Citation: S. Di Rubbo, N. G. Irani,, E. Russinova, PP2A Phosphatases: The "On-Off" Regulatory Switches of Brassinosteroid Signaling. Sci. Signal. 4, pe25 (2011).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DWARF AND LOW-TILLERING Acts as a Direct Downstream Target of a GSK3/SHAGGY-Like Kinase to Mediate Brassinosteroid Responses in Rice.
H. Tong, L. Liu, Y. Jin, L. Du, Y. Yin, Q. Qian, L. Zhu, and C. Chu (2012)
PLANT CELL 24, 2562-2577
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882