Science Signaling Podcast: 24 May 2011

James F. Martin¹, Valeri Vasioukhin^2,3, Mark R. Silvis², and Annalisa M. VanHook⁴

¹ Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA.
² Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
³ Department of Pathology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
⁴ Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This Podcast features conversations with authors of articles related to Hippo signaling that appear in Science and Science Signaling. James Martin discusses his group’s finding that Hippo signaling regulates the size of the mouse heart by antagonizing Wnt signaling through a mechanism that involves cooperation between the transcription factors Yap and β-catenin, as described in a Research Report published in the 22 April 2011 issue of Science. Valeri Vasioukhin and Mark Silvis discuss their findings related to Hippo signaling in tumorigenesis, as reported in the 24 May 2011 issue of Science Signaling. They report that the adhesion protein αE-catenin acts as a tumor suppressor by regulating the localization and activity of the transcriptional coactivator Yap, which is also regulated by Hippo signaling.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cancer
α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

Mark R. Silvis, Bridget T. Kreger, Wen-Hui Lien, Olga Klezovitch, G. Marianna Rudakova, Fernando D. Camargo, Dan M. Lantz, John T. Seykora, and Valeri Vasioukhin (24 May 2011)
Sci. Signal. 4 (174), ra33. [DOI: 10.1126/scisignal.2001823]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Development
A Hippo-Sized Heart

Annalisa M. VanHook (26 April 2011)
Sci. Signal. 4 (170), ec117. [DOI: 10.1126/scisignal.4170ec117]
 |  Abstract »

EDITORS' CHOICE
Regeneration
Hippo Checks Regeneration

Annalisa M. VanHook (9 November 2010)
Sci. Signal. 3 (147), ec342. [DOI: 10.1126/scisignal.3147ec342]
 |  Abstract »

EDITORS' CHOICE
Developmental Biology
Kibra Prevents Hippos

Wei Wong (2 March 2010)
Sci. Signal. 3 (111), ec67. [DOI: 10.1126/scisignal.3111ec67]
 |  Abstract »

RESEARCH ARTICLES
Cell Biology
Hippo Pathway–Dependent and –Independent Roles of RASSF6

Mitsunobu Ikeda, Akira Kawata, Misa Nishikawa, Yuko Tateishi, Masato Yamaguchi, Kentaro Nakagawa, Susumu Hirabayashi, Yijun Bao, Shiho Hidaka, Yukio Hirata, and Yutaka Hata (29 September 2009)
Sci. Signal. 2 (90), ra59. [DOI: 10.1126/scisignal.2000300]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Developmental Biology
Focus Issue: Organ Development from Beginning to End

Annalisa M. VanHook (9 December 2008)
Sci. Signal. 1 (49), eg10. [DOI: 10.1126/scisignal.149eg10]
 |  Abstract »  |  Full Text »  |  PDF »

In Science Magazine

REPORTS
Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

Todd Heallen, Min Zhang, Jun Wang, Margarita Bonilla-Claudio, Ela Klysik, Randy L. Johnson, and James F. Martin (22 April 2011)
Science 332 (6028), 458. [DOI: 10.1126/science.1199010]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »