Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 14 June 2011
Vol. 4, Issue 177, p. ec165
[DOI: 10.1126/scisignal.4177ec165]


Cell Biology mTOR Substrates Revealed

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

The protein kinase mammalian target of rapamycin (mTOR) functions in protein complexes (mTORC1 and mTORC2) that are activated in response to agents such as growth factors and insulin and has important roles in regulating many physiological responses, including cell growth, proliferation, metabolism, and cell survival (see the Perspective by Yea and Fruman). Hsu et al. and Yu et al. conducted proteomic screens to identify substrates of mTORC1 and mTORC2 kinases. Numerous proteins that appear to be direct substrates were identified, including a new mTOR substrate, Grb10. Grb10 is an adaptor molecule that functions in the formation of signaling complexes associated with growth factor receptor tyrosine kinases.

P. P. Hsu, S. A. Kang, J. Rameseder, Y. Zhang, K. A. Ottina, D. Lim, T. R. Peterson, Y. Choi, N. S. Gray, M. B. Yaffe, J. A. Marto, D. M. Sabatini, The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317–1322 (2011). [Abstract] [Full Text]

Y. Yu, S.-O. Yoon, G. Poulogiannis, Q. Yang, X. M. Ma, J. Villén, N. Kubica, G. R. Hoffman, L. C. Cantley, S. P. Gygi, J. Blenis, Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322–1326 (2011). [Abstract] [Full Text]

S. S. Yea, D. A. Fruman, New mTOR targets Grb attention. Science 332, 1270–1271 (2011). [Abstract] [Full Text]

Citation: L. B. Ray, mTOR Substrates Revealed. Sci. Signal. 4, ec165 (2011).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882