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Sci. Signal., 21 June 2011
Vol. 4, Issue 178, p. jc4
[DOI: 10.1126/scisignal.2002052]


Partners in Crime: Ubiquitin-Mediated Degradation and Autophagy

Shashikanth M. Sriram1*, Dong Hoon Han2, and Sung Tae Kim1

1 The authors are graduate students at the Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
2 The author is a graduate student at the World Class University (WCU) Program, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul 110-799, Korea.

Abstract: Recent focus on autophagy research has led to new insights on the involvement of ubiquitin (Ub)–mediated signaling as a selectivity factor in autophagy, which is generally considered a nonselective global degradation system. Emerging reports have demonstrated active crosstalk between the Ub-dependent proteolytic system and autophagy. This article highlights recent reports describing Ub-mediated selective autophagy regulated by the Toll-like receptor 4–induced immune response.

* Corresponding author. E-mail, shs77{at}

Citation: S. M. Sriram, D. H. Han, S. T. Kim, Partners in Crime: Ubiquitin-Mediated Degradation and Autophagy. Sci. Signal. 4, jc4 (2011).

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