Sci. Signal., 26 July 2011
Developmental Biology Dicty Tiger Nixes Cheaters
Science, AAAS, Cambridge CB2 1LQ, UK
Cells within aggregates of the social amoeba, Dictyostelium discoideum, differentiate to form fruiting bodies containing a mixture of spores from different strains (genotypes). In the process of forming the stalk of the fruiting body, cells die. So what is to stop some strains from "cheating" by not participating in the sacrificial donation of cells to the dying stalk? Hirose et al. studied an amoeba that possesses polymorphic genes called tiger, which mediate self-recognition, signaling, and developmental regulation. In a series of deletion and replacement experiments, a complementary pair of tiger alleles was sufficient to exclude cheaters from the fruiting body.
Citation: C. Ash, Dicty Tiger Nixes Cheaters. Sci. Signal. 4, ec210 (2011).
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