Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 30 August 2011
Vol. 4, Issue 188, p. ec237
[DOI: 10.1126/scisignal.4188ec237]


Cell Adhesion Playing Checkers

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Developmental patterning is very important in the arrangements of cells within organs and tissues. The organ of Corti in the inner ear contains mechanosensory hair cells that are interdigitated with nonsensory supporting cells. During development, these two cell types are arranged in a checkerboard-like pattern. Togashi et al. worked in mice (see the Perspective by Choi and Peifer) to show that the immunoglobulin-like cell-cell adhesion molecules nectin-1 and nectin-3 play a key role in this checkerboard-like patterning through their heterophilic interactions. Mice lacking either nectin-1 or nectin-3 fail to organize their auditory epithelia properly. Thus, differential cell adhesion can control the spatial pattern of cells in a tissue.

H. Togashi, K. Kominami, M. Waseda, H. Komura, J. Miyoshi, M. Takeichi, Y. Takai, Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. Science 333, 1144–1147 (2011). [Abstract] [Full Text]

W. Choi, M. Peifer, Arranging a cellular checkerboard. Science 333, 1099–1100 (2011). [Abstract] [Full Text]

Citation: S. M. Hurtley, Playing Checkers. Sci. Signal. 4, ec237 (2011).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882