Sci. Signal., 13 September 2011
Calcium Signaling Tug at the Heart Strings
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
When the heart fills with blood, the muscle cells relax and stretch. To find out how individual heart muscle cells, or cardiomyocytes, respond to stretching, Prosser et al. (see the Perspective by Hidalgo and Donoso) suspended single rodent cardiomyocytes between glass rods, stretched them just a little, and monitored the release of tiny amounts of calcium through channels known as ryanodine receptors. Loading the cells with fluorescent dyes sensitive to the binding of calcium or reactive oxygen species (ROS) revealed that activation of the enzyme nicotinamide adenine dinucleotide phosphate oxidase 2 triggered ROS generation, which then led to opening of the ryanodine receptor pore. Cells from animals with muscular dystrophy showed excessive calcium release, which may contribute to impaired muscle function.
Citation: L. B. Ray, Tug at the Heart Strings. Sci. Signal. 4, ec250 (2011).
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