Sci. Signal., 13 September 2011
Neuroscience Unraveling Neuropathic Pain
Peter R. Stern
Science, AAAS, Cambridge CB2 1LQ, UK
Neuropathic pain results from nerve damage and is evoked by trauma in conditions ranging from shingles and diabetes to cancer chemotherapy, but the mechanisms remain poorly understood. By using gene knockouts in animal models, Emery et al. found that a member of the HCN ion channel family is important in both inflammatory and neuropathic pain. This discovery opens up the possibility of developing specific antagonists to treat neuropathic pain.
Citation: P. R. Stern, Unraveling Neuropathic Pain. Sci. Signal. 4, ec257 (2011).
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