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Sci. Signal., 13 September 2011
Vol. 4, Issue 190, p. pc18
[DOI: 10.1126/scisignal.2002481]


Science Signaling Podcast: 13 September 2011

Juan A. Recio1 and Annalisa M. VanHook2

1 Mouse Models and Cancer Laboratory, Anatomy Pathology Department, Vall d’Hebron Research Institute, Barcelona 08035, Spain.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 13 September 2011 issue of Science Signaling. Nerve growth factor (NGF) and epidermal growth factor (EGF) both activate signaling through the extracellular signal–regulated kinase (ERK) cascade, but have different effects on PC12 neuroendocrine cells. Whereas NGF induces differentiaion, EGF stimulates proliferation. Juan Recio discusses his group’s finding that the ability of these growth factors to elicit distinct biological responses despite activating the same intracellular signaling pathway depends upon methylation of RAF.

Citation: J. A. Recio, A. M. VanHook, Science Signaling Podcast: 13 September 2011. Sci. Signal. 4, pc18 (2011).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882