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Sci. Signal., 20 September 2011
Vol. 4, Issue 191, p. ec265
[DOI: 10.1126/scisignal.4191ec265]


Neuroscience Gut Reaction

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

Guanylyl cyclase-C (GC-C) is a membrane protein that functions as a receptor for peptide hormones produced in the gut. When stimulated, it produces the signaling second messenger guanosine 3',5'-monophosphate. Gong et al. report that GC-C also functions in the mouse midbrain. Neurons in this area use the neurotransmitter dopamine, and activation of GC-C caused enhanced responsiveness of neurons to the neurotransmitters glutamate and acetylcholine. Behavioral abnormalities of mice lacking GC-C expression showed some similarity to behaviors observed in humans with attention deficit hyperactivity disorder.

R. Gong, C. Ding, J. Hu, Y. Lu, F. Liu, E. Mann, F. Xu, M. B. Cohen, M. Luo, Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333, 1642–1646 (2011). [Abstract] [Full Text]

Citation: L. B. Ray, Gut Reaction. Sci. Signal. 4, ec265 (2011).

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