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Sci. Signal., 4 October 2011
Vol. 4, Issue 193, p. pe41
[DOI: 10.1126/scisignal.2002436]


A WNTer Revisit: New Faces of β-Catenin and TCFs in Pluripotency

Kazuhide Watanabe and Xing Dai*

Department of Biological Chemistry, School of Medicine, D250 Med Sci I, University of California, Irvine, CA 92697–1700, USA.

Abstract: New evidence has revealed interesting aspects of how the Wnt–β-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt–β-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.

* Corresponding author. E-mail, xdai{at}

Citation: K. Watanabe, X. Dai, A WNTer Revisit: New Faces of β-Catenin and TCFs in Pluripotency. Sci. Signal. 4, pe41 (2011).

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