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Sci. Signal., 25 October 2011
Vol. 4, Issue 196, p. pc22
[DOI: 10.1126/scisignal.2002560]


Science Signaling Podcast: 25 October 2011

Adam A. Friedman1, 2, 3, Norbert Perrimon1, 2, and Annalisa M. VanHook4

1 Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
2 Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
3 Harvard–MIT Division of Health Sciences and Technology, Boston, MA 02115, USA.
4 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with authors of a Research Resource published in the 25 October 2011 issue of Science Signaling. Although the extracellular signal–regulated kinase (ERK) pathway has been extensively studied, our understanding of all the regulatory interactions that modulate signaling is by no means complete. Adam Friedman and Norbert Perrimon discuss their group’s strategy of combining functional and genomics approaches to identify common and specific regulators of ERK signaling in the fruit fly Drosophila melanogaster. The ERK pathway plays an important role in normal developmental and physiological contexts as well as in disease states, such as tumorigenesis.

Citation: A. A. Friedman, N. Perrimon, A. M. VanHook, Science Signaling Podcast: 25 October 2011. Sci. Signal. 4, pc22 (2011).

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