Sci. Signal., 1 November 2011
Science Signaling Podcast: 1 November 2011
Xiaoxia Li1 and Annalisa M. VanHook2
1 Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her groups identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.
Citation: X. Li, A. M. VanHook, Science Signaling Podcast: 1 November 2011. Sci. Signal. 4, pc23 (2011).
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