Science Signaling Podcast: 8 November 2011

David M. Sabatini^{1,2, 3,4,5} and Annalisa M. VanHook⁶

¹ Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
² Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
³ David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
⁴ Broad Institute, Seven Cambridge Center, Cam- bridge, MA 02142, USA.
⁵ Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
⁶ Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Report published in the 4 November 2011 issue of Science. Signaling through mTORC1 (the mammalian target of rapamycin complex 1) promotes cell growth by stimulating protein synthesis. The activity of mTORC1 is regulated by cellular nutrient and energy status as well as growth factors. The presence of amino acids stimulates the translocation of mTORC1 to the surface of the lysosome, where it is activated. Zoncu and colleagues report that the vacuolar ATPase is required for amino acids to activate mTORC1. Senior author David Sabatini discusses these findings.

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EDITORS' CHOICE
mTORC1 Signaling
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L. Bryan Ray (8 November 2011)
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In Science Magazine

REPORTS
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H⁺-ATPase

Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, and David M. Sabatini (4 November 2011)
Science 334 (6056), 678. [DOI: 10.1126/science.1207056]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supporting Online Material »