Sci. Signal., 15 November 2011
Immunology Viral Control
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
Chronic viral infections, like the human immunodeficiency virus and the hepatitis C virus, result in altered immune responses that help to keep the infection under control and limit virus-related pathology. Harker et al. now show that the cytokine interleukin-6 (IL-6) is required for resolving a chronic viral infection in mice. Surprisingly, IL-6 was not required during the acute stages of viral infection, but it was required once a chronic infection was established.
J. A. Harker, G. M. Lewis, L. Mack, E. I. Zuniga, Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334, 825–829 (2011). [Abstract] [Full Text]
Citation: K. L. Mueller, Viral Control. Sci. Signal. 4, ec321 (2011).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882