Sci. Signal., 22 November 2011
Microbiology Bacterial Protection
Science, AAAS, Cambridge CB2 1LQ, UK
Most bacteria are capable of producing hydrogen sulfide and use a trio of enzymes to do so. Classically, this gas was considered a by-product of sulfur metabolism, but knowing that nitric oxide protects Gram-positive bacteria against oxidative stress, Shatalin et al. (see the Perspective by Belenky and Collins) discovered that H2S probably does likewise. When the H2S-producing enzymes were inactivated, bacteria became more susceptible to antibiotics unless supplied with a source of H2S.
Citation: C. Ash, Bacterial Protection. Sci. Signal. 4, ec329 (2011).
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