Direct Delivery Mechanisms of Morphogen Dispersion

Sougata Roy and Thomas B. Kornberg^*

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.

A Presentation from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration, and Disease, Kolymbari, Crete, 23 to 25 June 2011.

Abstract: This Presentation focuses on how morphogen signaling proteins disperse across developmental fields. Although the steady-state distributions of morphogen signaling proteins have been described well in a number of contexts, the mechanisms that generate these distributions have remained uncertain. Results presented here show that these proteins transfer from producing to target cells at points of direct contact, even when the producing and target cells are not immediate neighbors.

* Presenter and corresponding author. E-mail: tom.kornberg{at}ucsf.edu

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PRESENTATIONS
Cell Biology
Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to G_i Proteins

Ariel H. Polizio, Pilar Chinchilla, Xiaolen Chen, David R. Manning, and Natalia A. Riobo (22 November 2011)
Sci. Signal. 4 (200), pt7. [DOI: 10.1126/scisignal.2002396]
 |  Abstract »  |  Full Text »  |  PDF »  |  Slideshow »

PERSPECTIVES
Cell Biology
Barcoding Hedgehog for Intracellular Transport

Thomas B. Kornberg (22 November 2011)
Sci. Signal. 4 (200), pe44. [DOI: 10.1126/scisignal.2002447]
 |  Abstract »  |  Full Text »  |  PDF »

PRESENTATIONS
Cancer
Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases

Ariel Ruiz i Altaba (22 November 2011)
Sci. Signal. 4 (200), pt9. [DOI: 10.1126/scisignal.2002540]
 |  Abstract »  |  Full Text »  |  PDF »  |  Slideshow »

EDITORIAL GUIDES
Cell Biology
Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease

Annalisa M. VanHook (22 November 2011)
Sci. Signal. 4 (200), eg10. [DOI: 10.1126/scisignal.2002653]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Development
Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling

Ying Su, Jason K. Ospina, Junzheng Zhang, Andrew P. Michelson, Adam M. Schoen, and Alan Jian Zhu (5 July 2011)
Sci. Signal. 4 (180), ra43. [DOI: 10.1126/scisignal.2001747]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Developmental Biology
The cis-Regulatory Logic of Hedgehog Gradient Responses: Key Roles for Gli Binding Affinity, Competition, and Cooperativity

David S. Parker, Michael A. White, Andrea I. Ramos, Barak A. Cohen, and Scott Barolo (7 June 2011)
Sci. Signal. 4 (176), ra38. [DOI: 10.1126/scisignal.2002077]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cell Biology
New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing

Elena Rainero and Jim C. Norman (3 May 2011)
Sci. Signal. 4 (171), pe24. [DOI: 10.1126/scisignal.2002053]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Developmental Biology
Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient

Andreu Casali (24 August 2010)
Sci. Signal. 3 (136), ra63. [DOI: 10.1126/scisignal.2001059]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Development
Wingless Promotes Proliferative Growth in a Gradient-Independent Manner

Luis Alberto Baena-Lopez, Xavier Franch-Marro, and Jean-Paul Vincent (6 October 2009)
Sci. Signal. 2 (91), ra60. [DOI: 10.1126/scisignal.2000360]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: