Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 29 November 2011
Vol. 4, Issue 201, p. ec335
[DOI: 10.1126/scisignal.4201ec335]

EDITORS' CHOICE

Cancer Primed for Death

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

Decades after their introduction into the clinic, cytotoxic chemotherapeutic drugs continue to be the mainstay of cancer patient care. Why chemotherapeutic drugs are effective in some tumors and not others is not fully understood. Ni Chonghaile et al. (see the Perspective by Reed) hypothesized that differences in chemotherapeutic response might be due to pretreatment differences in the readiness of tumor cells to undergo apoptosis (a form of cell death), a measurable property that they call "mitochondrial priming." Consistent with this idea, patients with highly primed cancers were found to have a superior clinical response to chemotherapy. In vitro manipulations that increased mitochondrial priming in tumor cells enhanced their sensitivity to chemotherapy.

T. Ni Chonghaile, K. A. Sarosiek, T.-T. Vo, J. A. Ryan, A. Tammareddi, V. Del Gaizo Moore, J. Deng, K. C. Anderson, P. Richardson, Y.-T. Tai, C. S. Mitsiades, U. A. Matulonis, R. Drapkin, R. Stone, D. J. DeAngelo, D. J. McConkey, S. E. Sallan, L. Silverman, M. S. Hirsch, D. Ruben Carrasco, A. Letai, Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334, 1129–1133 (2011). [Abstract] [Full Text]

J. C. Reed, Priming cancer cells for death. Science 334, 1075–1076 (2011). [Abstract] [Full Text]

Citation: P. A. Kiberstis, Primed for Death. Sci. Signal. 4, ec335 (2011).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882