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Sci. Signal., 20 December 2011
Vol. 4, Issue 204, p. pc26
[DOI: 10.1126/scisignal.2002740]


Science Signaling Podcast: 20 December 2011

Peter H. Krammer1 and Annalisa M. VanHook2

1 Division of Immunogenetics (D030), Tumor Immunology Program, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with the senior author of a Research Article published in the 20 December 2011 issue of Science Signaling. Peter Krammer discusses his group’s finding that suppression of conventional T cells by regulatory T cells involves inhibition of calcium signaling downstream of the T cell receptor. Understanding the mechanisms by which regulatory T cells suppress conventional T cells is important because too much suppression can dampen the antitumor response, and too little suppression can lead to autoimmune disease.

Citation: P. H. Krammer, A. M. VanHook, Science Signaling Podcast: 20 December 2011. Sci. Signal. 4, pc26 (2011).

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