Sci. Signal., 10 January 2012
Plant Biology Musical Chairs
Pamela J. Hines
Science, AAAS, Washington, DC 20005, USA
The plant hormone abscisic acid (ABA) helps plants to respond to changes in the environment, such as drought. Physiological responses are initiated when ABA binds to its receptor. In the absence of ABA, downstream kinases are held inactive by phosphatases. Soon et al. (see the Perspective by Leung) now show that both the hormone-receptor complex and the downstream kinase bind to the same site on the phosphatase. Thus, in the presence of hormone, the phosphatase is occupied and unable to interfere with downstream kinase activity.
F.-F. Soon, L.-M. Ng, X. E. Zhou, G. M. West, A. Kovach, M. H. E. Tan, K. M. Suino-Powell, Y. He, Y. Xu, M. J. Chalmers, J. S. Brunzelle, H. Zhang, H. Yang, H. Jiang, J. Li, E.-L. Yong, S. Cutler, J.-K. Zhu, P. R. Griffin, K. Melcher, H. E. Xu, Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science 335, 85–88 (2012). [Abstract] [Full Text]
Citation: P. J. Hines, Musical Chairs. Sci. Signal. 5, ec13 (2012).
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