Sci. Signal., 10 January 2012
Extracellular Matrix Going LARGE
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Dystroglycan (DG) is a highly glycosylated extracellular matrix (ECM) receptor involved in a variety of physiological processes, including maintenance of skeletal muscle membrane integrity and the structure and function of the central nervous system. The like-acetylglucosaminyltransferase (LARGE) is responsible for posttranslational modifications of alpha-dystroglycan (α-DG) required for its function. Now, Inamori et al. demonstrate that LARGE is a bifunctional glycosyltransferase able to transfer xylose and glucuronic acid. These modifications allow α-DG to bind the laminin-G domain–containing ECM ligands: laminin, agrin, and neurexin.
K.-i. Inamori, T. Yoshida-Moriguchi, Y. Hara, M. E. Anderson, L. Yu, K. P. Campbell, Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science 335, 93–96 (2012). [Abstract] [Full Text]
Citation: S. M. Hurtley, Going LARGE. Sci. Signal. 5, ec16 (2012).
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