Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 17 January 2012
Vol. 5, Issue 207, p. pe2
[DOI: 10.1126/scisignal.2002680]

PERSPECTIVES

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

Patrick A. Lewis* and Claudia Manzoni*

Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Abstract: Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson’s disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn’s disease. Here, we examine how LRRK2’s role as a signaling hub in the cell could lead to diverse pathologies.

* Corresponding authors. E-mail, patrick.lewis{at}ucl.ac.uk (P.A.L.); c.manzoni{at}ucl.ac.uk (C.M.)

Citation: P. A. Lewis, C. Manzoni, LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? Sci. Signal. 5, pe2 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The regulation and deregulation of Wnt signaling by PARK genes in health and disease.
D. C. Berwick and K. Harvey (2014)
J Mol Cell Biol 6, 3-12
   Abstract »    Full Text »    PDF »
Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies.
G. Skibinski, K. Nakamura, M. R. Cookson, and S. Finkbeiner (2014)
J. Neurosci. 34, 418-433
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882