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Sci. Signal., 17 January 2012
Vol. 5, Issue 207, p. pe2
[DOI: 10.1126/scisignal.2002680]

PERSPECTIVES

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

Patrick A. Lewis* and Claudia Manzoni*

Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Abstract: Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson’s disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn’s disease. Here, we examine how LRRK2’s role as a signaling hub in the cell could lead to diverse pathologies.

* Corresponding authors. E-mail, patrick.lewis{at}ucl.ac.uk (P.A.L.); c.manzoni{at}ucl.ac.uk (C.M.)

Citation: P. A. Lewis, C. Manzoni, LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? Sci. Signal. 5, pe2 (2012).

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