Science Signaling Podcast: 7 February 2012

Kathryn M. Taylor¹ and Annalisa M. VanHook²

¹ Breast Cancer Molecular Pharmacology Group, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VIIth Avenue, Cardiff, CF10 3NB, UK.
² Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features a conversation with an author of a Research Article published in the 7 February 2012 issue of Science Signaling. Kathryn Taylor discusses her group’s finding that the kinase CK2 promotes the formation of intracellular zinc waves that modulate cell proliferation and migration. When zinc is released from intracellular stores, it acts as a second messenger to promote the activity of tyrosine kinases that are involved in cell proliferation and migration. Taylor et al. found that the kinase CK2, which plays an important role in cell proliferation, phosphorylates the zinc channel ZIP7 to promote zinc release from the endoplasmic reticulum.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cell Biology
Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7

Kathryn M. Taylor, Stephen Hiscox, Robert I. Nicholson, Christer Hogstrand, and Peter Kille (7 February 2012)
Sci. Signal. 5 (210), ra11. [DOI: 10.1126/scisignal.2002585]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cell Biology
Protein Kinases Curb Cell Death

Odile Filhol and Claude Cochet (10 May 2011)
Sci. Signal. 4 (172), pe26. [DOI: 10.1126/scisignal.2001921]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Caspases
A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling

James S. Duncan, Jacob P. Turowec, Kelly E. Duncan, Greg Vilk, Chenggang Wu, Bernhard Lüscher, Shawn S.-C. Li, Greg B. Gloor, and David W. Litchfield (10 May 2011)
Sci. Signal. 4 (172), ra30. [DOI: 10.1126/scisignal.2001682]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

MEETING REPORTS
Neuroscience
Zinc Bells Rang in Jerusalem!

Michal Hershfinkel, Elias Aizenman, Glen Andrews, and Israel Sekler (6 July 2010)
Sci. Signal. 3 (129), mr2. [DOI: 10.1126/scisignal.3129mr2]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Physiology
Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

Yoshiki Tsuchiya, Makoto Akashi, Mitsuhiro Matsuda, Kyoko Goto, Yoshihiko Miyata, Koichi Node, and Eisuke Nishida (2 June 2009)
Sci. Signal. 2 (73), ra26. [DOI: 10.1126/scisignal.2000305]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

MEETING REPORTS
Metals
Meeting Report: Zinc Signals 2007—Expanding Roles of the Free Zinc Ion in Biology

Cathleen Frederickson, Christopher J. Frederickson, Wolfgang Maret, Harold Sandstead, Leonard Giblin, and Richard Thompson (6 November 2007)
Sci. STKE 2007 (411), pe61. [DOI: 10.1126/stke.4112007pe61]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORIAL GUIDES
STKE Editorial Guides
Focus Issue: Metals in Biology: Coin for the Signaling Realm?

Elizabeth M. Adler, Nancy R. Gough, and Lisa D. Chong (13 May 2003)
Sci. STKE 2003 (182), eg7. [DOI: 10.1126/scisignal.1822003eg7]
 |  Full Text »  |  PDF »