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Sci. Signal., 6 March 2012
Vol. 5, Issue 214, p. pc5
Science Signaling Podcast: 6 March 2012
John G. Albeck1,
Joan S. Brugge1, and
Annalisa M. VanHook2
1 Department of Cell Biology, Harvard Medical School, Boston, MA, USA. 2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.
This Podcast features a conversation with authors of a Research Article published in the 6 March 2012 issue of Science Signaling. Joan Brugge and John Albeck discuss their work on a mechanism of crosstalk between growth factor signaling pathways that control proliferation in breast epithelial cells. Insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF) both promoted proliferation of breast epithelial cells, but only EGF stimulated proliferation on its own. IGF-1 did not stimulate proliferation on its own, but instead enhanced the proliferative response to EGF. The signaling cascades stimulated by EGF and IGF-1, which are commonly used as indicators of oncogenic signaling, differentially regulated the activity of the cell cycle inhibitor p57. Thus, the status of p57 may indicate which pathway to inhibit in breast cancer.
Citation: J. G. Albeck, J. S. Brugge, A. M. VanHook, Science Signaling Podcast: 6 March 2012. Sci. Signal.5, pc5 (2012).
Adam A. Friedman, George Tucker, Rohit Singh, Dong Yan, Arunachalam Vinayagam, Yanhui Hu, Richard Binari, Pengyu Hong, Xiaoyun Sun, Maura Porto, Svetlana Pacifico, Thilakam Murali, Russell L. Finley, Jr., John M. Asara, Bonnie Berger, and Norbert Perrimon (25 October 2011) Sci. Signal.4 (196), rs10.
[DOI: 10.1126/scisignal.2002029] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Nagalingam R. Sundaresan, Vinodkumar B. Pillai, Don Wolfgeher, Sadhana Samant, Prabhakaran Vasudevan, Vishwas Parekh, Hariharasundaram Raghuraman, John M. Cunningham, Madhu Gupta, and Mahesh P. Gupta (19 July 2011) Sci. Signal.4 (182), ra46.
[DOI: 10.1126/scisignal.2001465] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Roi Avraham, Aldema Sas-Chen, Ohad Manor, Israel Steinfeld, Reut Shalgi, Gabi Tarcic, Noa Bossel, Amit Zeisel, Ido Amit, Yaara Zwang, Espen Enerly, Hege G. Russnes, Francesca Biagioni, Marcella Mottolese, Sabrina Strano, Giovanni Blandino, Anne-Lise Børresen-Dale, Yitzhak Pilpel, Zohar Yakhini, Eran Segal, and Yosef Yarden (1 June 2010) Sci. Signal.3 (124), ra43.
[DOI: 10.1126/scisignal.2000876] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Paul H. Huang, Alexander M. Xu, and Forest M. White (8 September 2009) Sci. Signal.2 (87), re6.
[DOI: 10.1126/scisignal.287re6] |Gloss »|Abstract »|Full Text »|PDF »
Xiao R. Cao, Nancy L. Lill, Natasha Boase, Peijun P. Shi, David R. Croucher, Hongbo Shan, Jing Qu, Eileen M. Sweezer, Trenton Place, Patricia A. Kirby, Roger J. Daly, Sharad Kumar, and Baoli Yang (23 September 2008) Sci. Signal.1 (38), ra5.
[DOI: 10.1126/scisignal.1160940] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »