Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 13 March 2012
Vol. 5, Issue 215, p. ec78
[DOI: 10.1126/scisignal.2003030]


Immunology Making Immune Cells Young Again

Kristen L. Mueller

Science, AAAS, Washington, DC 20005, USA

Hematopoiesis, the development of the immune system, occurs in distinct waves. The immune system is first populated by cells that arise from fetal hematopoietic stem cells (HSCs) and then later by cells derived from adult HSCs. Furthermore, fetal HSCs give rise to lymphocytes with innate immunelike properties, whereas adult HSCs give rise to classical T and B cells. Yuan et al. now uncover the molecular mechanism behind these distinct waves of hematopoiesis. Expression of the RNA binding proteins Lin28 and Lin28b is enriched in fetal hematopoietic stem/progenitor cells (HSPCs) in mice and humans. Ectopic expression of Lin28 in mouse adult HSPCs was sufficient to induce the differentiation of both classical and innatelike lymphocyte lineages.

J. Yuan, C. K. Nguyen, X. Liu, C. Kanellopoulou, S. A. Muljo, Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 335, 1195–1200 (2012). [Abstract] [Full Text]

Citation: K. L. Mueller, Making Immune Cells Young Again. Sci. Signal. 5, ec78 (2012).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882