Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 13 March 2012
Vol. 5, Issue 215, p. pe10
[DOI: 10.1126/scisignal.2002943]

PERSPECTIVES

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

Toren Finkel*

Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, MD 20892, USA.

Abstract: There is a growing appreciation that oxidants such as hydrogen peroxide (H2O2) and gases such as nitric oxide (NO) and hydrogen sulfide (H2S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small, diffusible molecules (H2O2, NO, H2S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.

* Corresponding author. E-mail: finkelt{at}nih.gov

Citation: T. Finkel, From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate. Sci. Signal. 5, pe10 (2012).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conceptual Framework for Cutting the Pancreatic Cancer Fuel Supply.
A. Le, N. V. Rajeshkumar, A. Maitra, and C. V. Dang (2012)
Clin. Cancer Res. 18, 4285-4290
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882