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Sci. Signal., 13 March 2012
Vol. 5, Issue 215, p. pe10
[DOI: 10.1126/scisignal.2002943]


From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

Toren Finkel*

Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, MD 20892, USA.

Abstract: There is a growing appreciation that oxidants such as hydrogen peroxide (H2O2) and gases such as nitric oxide (NO) and hydrogen sulfide (H2S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small, diffusible molecules (H2O2, NO, H2S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.

* Corresponding author. E-mail: finkelt{at}

Citation: T. Finkel, From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate. Sci. Signal. 5, pe10 (2012).

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