Sci. Signal., 27 March 2012
Alzheimer's Disease Reversing Decline?
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Apolipoprotein E (apoE) normally helps in the clearance of β-amyloid (Aβ) from the brain, a process that is compromised in Alzheimers disease. Cramer et al. (see the Perspective by Strittmatter) now show that a drug that increases apoE expression rapidly promoted soluble Aβ clearance in a mouse model of Alzheimers disease. The drug also improved cognitive, social, and olfactory performance and rapidly improved neural circuit function. Similar therapeutics may potentially help to ameliorate the symptoms of Alzheimers disease and its prodromal states.
P. E. Cramer, J. R. Cirrito, D. W. Wesson, C. Y. D. Lee, J. C. Karlo, A. E. Zinn, B. T. Casali, J. L. Restivo, W. D. Goebel, M. J. James, K. R. Brunden, D. A. Wilson, G. E. Landreth, ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335, 1503–1506 (2012). [Abstract] [Full Text]
Citation: S. M. Hurtley, Reversing Decline? Sci. Signal. 5, ec98 (2012).
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