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Sci. Signal., 1 May 2012
Vol. 5, Issue 222, p. pe19
[DOI: 10.1126/scisignal.2002917]

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Phosphoinositides as Regulators of Protein-Chromatin Interactions

Keijo Viiri*{dagger}, Markku Mäki, and Olli Lohi

Paediatric Research Centre, University of Tampere, School of Medicine and Tampere University Hospital, 33520 Tampere, Finland.
{dagger} Present address: Division of Infection and Immunity and UCL Cancer Institute, University College London, London WC1E 6BT, UK.

Abstract: The molecular function of phospholipids in the nucleus has been only partially elucidated. The upsurge of epigenetic research has contributed to increased interest in nuclear phospholipids, such as phosphoinositides, and their involvement in gene transcription. However, the mechanisms by which phosphoinositides regulate transcription is still unknown at the molecular level. Certain phosphoinositide species can regulate protein-chromatin and protein–nucleic acid interactions, and specific nuclear target proteins link nuclear signaling lipids to gene expression. We propose that a phosphoinositide-mediated detachment of proteins from chromatin is a general biological mechanism that partly underlies the signaling effects of nuclear phosphoinositides.

* Corresponding author. E-mail: kviiri{at}yahoo.com; k.viiri{at}ucl.ac.uk

Citation: K. Viiri, M. Mäki, O. Lohi, Phosphoinositides as Regulators of Protein-Chromatin Interactions. Sci. Signal. 5, pe19 (2012).

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