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Sci. Signal., 12 June 2012
Vol. 5, Issue 228, p. pe26
[DOI: 10.1126/scisignal.2003181]


S-Nitrosylation Signaling in Escherichia coli

Ivan Gusarov and Evgeny Nudler*

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

Abstract: Most bacteria generate nitric oxide (NO) either aerobically by NO synthases or anaerobically from nitrite. Far from being a mere by-product of nitrate respiration, bacterial NO has diverse physiological roles. Many proteins undergo NO-mediated posttranslational modification (S-nitrosylation) in anaerobically grown Escherichia coli. The regulation of one such protein, OxyR, represents a redox signaling paradigm in which the same transcription factor controls different protective genes depending on its S-nitrosylation versus S-oxidation status. We discuss a structural model that may explain the remarkable stability and specificity of OxyR S-nitrosylation.

* Corresponding author. E-mail: evgeny.nudler{at}

Citation: I. Gusarov, E. Nudler, S-Nitrosylation Signaling in Escherichia coli. Sci. Signal. 5, pe26 (2012).

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