Sci. Signal., 26 June 2012
Science Signaling Podcast: 26 June 2012
Vassiliki A. Boussiotis1 and Annalisa M. VanHook2
1 Department of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Abstract: This Podcast features an interview with Vassiliki Boussiotis, senior author of a Research Article published in the 26 June 2012 issue of Science Signaling. Boussiotis discusses her groups investigation of a molecular mechanism by which autoreactive T cells are suppressed in the periphery. Most autoreactive T cells are eliminated by mechanisms of central tolerance in the bone marrow or thymus before they enter the circulation. Autoreactive T cells that escape central tolerance are suppressed or eliminated by mechanisms of peripheral tolerance. Boussiotiss group has described a molecular chain of events downstream of the receptor programmed death-1 (PD-1) that inhibit proliferation of autoreactive T cells.
Citation: V. A. Boussiotis, A. M. VanHook, Science Signaling Podcast: 26 June 2012. Sci. Signal. 5, pc14 (2012).
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