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Sci. Signal., 26 June 2012
Vol. 5, Issue 230, p. pc14
[DOI: 10.1126/scisignal.2003288]


Science Signaling Podcast: 26 June 2012

Vassiliki A. Boussiotis1 and Annalisa M. VanHook2

1 Department of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Vassiliki Boussiotis, senior author of a Research Article published in the 26 June 2012 issue of Science Signaling. Boussiotis discusses her group’s investigation of a molecular mechanism by which autoreactive T cells are suppressed in the periphery. Most autoreactive T cells are eliminated by mechanisms of central tolerance in the bone marrow or thymus before they enter the circulation. Autoreactive T cells that escape central tolerance are suppressed or eliminated by mechanisms of peripheral tolerance. Boussiotis’s group has described a molecular chain of events downstream of the receptor programmed death-1 (PD-1) that inhibit proliferation of autoreactive T cells.

Citation: V. A. Boussiotis, A. M. VanHook, Science Signaling Podcast: 26 June 2012. Sci. Signal. 5, pc14 (2012).

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