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Sci. Signal., 3 July 2012
Vol. 5, Issue 231, p. pe29
New Targets for Acetylation in Autophagy
Ahmed Hamaï and
INSERM U984, University Paris-Sud 11, 92296 Châtenay-Malabry, France
Macroautophagy is an evolutionarily conserved homeostatic process that mediates the degradation of long-lived cytoplasmic components in eukaryotes, which allows cells to survive stresses such as inflammation, hypoxia, and deprivation of nutrients or growth factors. At least 30 members of the Atg (autophagy-related) protein family orchestrate this degradative process. Additional complexity resides in the signaling networks controlling the autophagic process, which include various posttranslational modifications of key components. Evidence is accumulating that protein acetylation represents an evolutionarily conserved mechanism tightly regulating macroautophagy.