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Sci. Signal., 24 July 2012
Vol. 5, Issue 234, p. pc16
[DOI: 10.1126/scisignal.2003384]


Science Signaling Podcast: 24 July 2012

David G. Kirsch1,2, Chang-Lung Lee1, and Annalisa M. VanHook3

1 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
2 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
3 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with David Kirsch and Chang-Lung Lee, authors of a Research Article published in the 24 July 2012 issue of Science Signaling. Kirsch and Lee studied radiation-induced injury to the heart, focusing specifically on the vasculature in the heart and the role of the transcription factor p53. Previous studies had indicated that p53 promotes damage to the heart after various types of injury and stress, but Kirsch and Lee found that p53 protects cardiac endothelial cells—and thus the entire organ—from radiation-induced damage. The authors discuss these findings in the context of heart damage associated with radiation therapy in human patients

Citation: D. G. Kirsch, C.-L. Lee, A. M. VanHook, Science Signaling Podcast: 24 July 2012. Sci. Signal. 5, pc16 (2012).

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