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Sci. Signal., 31 July 2012
Vol. 5, Issue 235, p. pc17
[DOI: 10.1126/scisignal.2003402]


Science Signaling Podcast: 31 July 2012

Susan K. Pierce1 and Annalisa M. VanHook2

1 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Susan Pierce, senior author of a Research Article published in the 31 July 2012 issue of Science Signaling. The adaptive immune system allows vertebrates to recognize specific pathogens during an infection and remember them so that a subsequent exposure to the same pathogen elicits an even stronger response. Signaling through immunoglobulin G (IgG) B cell receptors (BCRs) in memory B cells is important for the immune system’s ability to respond to reinfection with a previously encountered pathogen. Pierce discusses her group’s recent discovery of a mechanism that promotes maximal signaling through IgG BCRs to ensure that memory B cells respond rapidly and robustly.

Citation: S. K. Pierce, A. M. VanHook, Science Signaling Podcast: 31 July 2012. Sci. Signal. 5, pc17 (2012).

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