Sci. Signal., 4 September 2012
Innate Immunity A Double Escapee
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
The Toll-like receptors (TLRs) TLR2 and TLR7 are thought to contribute to the sensing of Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumonia, by the immune system. Mice deficient in these receptors, however, are still sensitive to infection with these bacteria. Oldenburg et al. now demonstrate that TLR13 also plays a role in detecting Gram-positive bacteria. TLR13 recognized a conserved region in the peptidyl transferase loop of bacterial 23S ribosomal RNA (rRNA). Intriguingly, this same sequence is modified by specific methyltransferases that confer resistance to erythromycin. Indeed, erythromycin-resistant bacteria were no longer detectible by TLR13.
M. Oldenburg, A. Krüger, R. Ferstl, A. Kaufmann, G. Nees, A. Sigmund, B. Bathke, H. Lauterbach, M. Suter, S. Dreher, U. Koedel, S. Akira, T. Kawai, J. Buer, H. Wagner, S. Bauer, H. Hochrein, C. J. Kirschning, TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance–forming modification. Science 337, 1111–1115 (2012). [Abstract] [Full Text]
Citation: K. L. Mueller, A Double Escapee. Sci. Signal. 5, ec232 (2012).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882