Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 4 September 2012
Vol. 5, Issue 240, p. ec232
[DOI: 10.1126/scisignal.2003546]


Innate Immunity A Double Escapee

Kristen L. Mueller

Science, AAAS, Washington, DC 20005, USA

The Toll-like receptors (TLRs) TLR2 and TLR7 are thought to contribute to the sensing of Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumonia, by the immune system. Mice deficient in these receptors, however, are still sensitive to infection with these bacteria. Oldenburg et al. now demonstrate that TLR13 also plays a role in detecting Gram-positive bacteria. TLR13 recognized a conserved region in the peptidyl transferase loop of bacterial 23S ribosomal RNA (rRNA). Intriguingly, this same sequence is modified by specific methyltransferases that confer resistance to erythromycin. Indeed, erythromycin-resistant bacteria were no longer detectible by TLR13.

M. Oldenburg, A. Krüger, R. Ferstl, A. Kaufmann, G. Nees, A. Sigmund, B. Bathke, H. Lauterbach, M. Suter, S. Dreher, U. Koedel, S. Akira, T. Kawai, J. Buer, H. Wagner, S. Bauer, H. Hochrein, C. J. Kirschning, TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance–forming modification. Science 337, 1111–1115 (2012). [Abstract] [Full Text]

Citation: K. L. Mueller, A Double Escapee. Sci. Signal. 5, ec232 (2012).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882