Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 25 September 2012
Vol. 5, Issue 243, p. pe42
[DOI: 10.1126/scisignal.2003526]

PERSPECTIVES

Cell Responses to Growth Factors: The Role of Receptor Tyrosine Kinase Intracellular Domain Fragments

Graham Carpenter1* and Ambra Pozzi2

1 Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.
2 Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

Abstract: Growth factor activation of receptor tyrosine kinases (RTKs) provokes well-described canonical second messenger pathways that transmit biochemical signals in the cytoplasm and to the nucleus to initiate cellular responses. The proteolytic liberation of intracellular domain fragments (ICDs) from activated RTKs and the nuclear translocation of these ICDs represent a more recently identified and noncanonical mechanism by which RTKs communicate with the nucleus. Several reports have added previously unknown facets to the ICD mechanism and have enlarged the scope of ICDs as second messengers.

* Corresponding author. E-mail: graham.carpenter{at}vanderbilt.edu

Citation: G. Carpenter, A. Pozzi, Cell Responses to Growth Factors: The Role of Receptor Tyrosine Kinase Intracellular Domain Fragments. Sci. Signal. 5, pe42 (2012).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882