Sci. Signal., 9 October 2012
Physiology Gut Heal Thyself
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
Foods, drugs, and pathogens all represent possible threats to our guts on a daily basis. Fortunately, the gut is quite good at repairing itself—but how? Working in mice, Miyoshi et al. (see the Perspective by Barrett) selectively injured intestinal crypts containing intestinal stem cells and observed the repair process. The noncanonical Wnt ligand, Wnt5a, was required for crypt regeneration. Wnt5a inhibited intestinal stem cell proliferation, which paradoxically promoted regeneration of crypt tissue.
H. Miyoshi, R. Ajima, C. T. Luo, T. P. Yamaguchi, T. S. Stappenbeck, Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science 338, 108–113 (2012). [Abstract] [Full Text]
Citation: K. L. Mueller, Gut Heal Thyself. Sci. Signal. 5, ec260 (2012).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882