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Sci. Signal., 23 October 2012
Vol. 5, Issue 247, p. pe47
[DOI: 10.1126/scisignal.2003511]

PERSPECTIVES

PKR-Dependent Inflammatory Signals

Rui Kang1 and Daolin Tang1*

1 Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract: Double-stranded RNA–dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor {kappa}B, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.

* To whom correspondence should be addressed. E-mail: tangd2{at}upmc.edu

Citation: R. Kang, D. Tang, PKR-Dependent Inflammatory Signals. Sci. Signal. 5, pe47 (2012).

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