Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 30 October 2012
Vol. 5, Issue 248, p. ec280
[DOI: 10.1126/scisignal.2003732]


Neuroscience On the Receiving End

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

One type of neuron, the hippocampal pyramidal neuron, forms two different types of synapses with two different downstream partners. When the partner is an oriens-lacunosum moleculare (O-LM) interneuron, the pyramidal neuron only releases its synaptic vesicles with a low probability. When the cell on the receiving end is a parvalbumin (PV)–positive interneuron, the likelihood of synaptic vesicle release is high. How can the postsynaptic cell change the release characteristics of the presynaptic cell? Sylwestrak and Ghosh (see the Perspective by McBain) describe how the extracellular leucine-rich repeat fibronectin domain containing 1 (Elfn1) protein in the postsynaptic OLM interneurons affects vesicle release probability in the presynaptic pyramidal neuron. Misexpression of Elfn1 in PV interneurons converted vesicle release to the OLM pattern. Thus, a regulator located in the postsynaptic cell can modulate the function of the synapse.

E. L. Sylwestrak, A. Ghosh, Elfn1 regulates target-specific release probability at CA1-interneuron synapses. Science 338, 536–540 (2012). [Abstract] [Full Text]

C. J. McBain, Decoding the neuronal tower of Babel. Science 338, 482–483 (2012). [Abstract] [Full Text]

Citation: P. J. Hines, On the Receiving End. Sci. Signal. 5, ec280 (2012).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882