Science Signaling Podcast: 6 November 2012

Michael A. Frohman¹ and Annalisa M. VanHook²

¹ Department of Pharmacological Sciences, Center for Developmental Genetics, and Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY 11794–5140, USA.
² Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This is an interview with Michael Frohman, senior author of a Research Article that appears in this issue of Science Signaling. Frohman’s group has investigated the role of the enzyme phospholipase D1 (PLD1) in the tumor microenvironment. PLD1 produces the lipid phosphatidic acid, which acts as a second messenger in many signaling pathways and promotes proliferation, survival, and metastasis of cancer cells. When tumor cells were implanted into mice lacking PLD1, the resulting tumors were smaller and less vascularized than those that developed in wild-type mice and produced fewer lung metastases. Treating wild-type mice with a PLD1 inhibitor also inhibited tumor growth and metastasis, suggesting that inhibiting the activity of PLD1 might be a useful approach for treating human cancers.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Cancer
Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis

Qin Chen, Tsunaki Hongu, Takanobu Sato, Yi Zhang, Wahida Ali, Julie-Ann Cavallo, Adrianus van der Velden, Huasong Tian, Gilbert Di Paolo, Bernhard Nieswandt, Yasunori Kanaho, and Michael A. Frohman (6 November 2012)
Sci. Signal. 5 (249), ra79. [DOI: 10.1126/scisignal.2003257]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cell Biology
Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

Brian M. Wiczer and George Thomas (27 March 2012)
Sci. Signal. 5 (217), pe13. [DOI: 10.1126/scisignal.2003019]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Platelet Biology
Impaired _IIbβ₃ Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

Margitta Elvers, David Stegner, Ina Hagedorn, Christoph Kleinschnitz, Attila Braun, Marijke E. J. Kuijpers, Michael Boesl, Qin Chen, Johan W. M. Heemskerk, Guido Stoll, Michael A. Frohman, and Bernhard Nieswandt (5 January 2010)
Sci. Signal. 3 (103), ra1. [DOI: 10.1126/scisignal.2000551]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »