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Sci. Signal., 4 December 2012
Vol. 5, Issue 253, p. pe53
[DOI: 10.1126/scisignal.2003630]


Cdc42 Oscillations in Yeasts

Felipe O. Bendezú and Sophie G. Martin*

Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Biophore Building, CH-1015 Lausanne, Switzerland

Abstract: A fundamental problem in cell biology is how cells define one or several discrete sites of polarity. Through mechanisms involving positive and negative feedback, the small Rho-family guanosine triphosphatase Cdc42 breaks symmetry in round budding yeast cells to define a single site of polarized cell growth. However, it is not clear how cells can define multiple sites of polarization concurrently. We discuss a study in which rod-shaped fission yeast cells, which naturally polarize growth at their two cell ends, exhibited oscillations of Cdc42 activity between these sites. We compare these findings with similar oscillatory behavior of Cdc42 detected in budding yeast cells and discuss the possible mechanism and functional outputs of these oscillations.

* Corresponding author. E-mail: sophie.martin{at}

Citation: F. O. Bendezú, S. G. Martin, Cdc42 Oscillations in Yeasts. Sci. Signal. 5, pe53 (2012).

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